By A. Reinberg
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Extra resources for Annual Review of Chronopharmacology. Volume 2
Table of Contents Forward I. E x p e r i m e n t a l I. 4 Synchronization and marker rhythms I. 2. 4. 1 Reference limits for single samples I. 4. 3 Peei—group and individualized chronodesms I. 4. 4 Remarks II Data acquisition I I I Introduc t ion II. 2 M a t h e m a t i c a l m o d e l s II. 1 R e l a t i o n s b e t w e e n theory II. 2. 2 S y s t e m s I I . 2 . 1 Q u a n t i f i c a t i o n p r o b l e m s 11. 3. 4 II. 3. 6 ARC and practice, Concept of signal Equidistant data* sampling theory Two different meanings of "sampling" Missing data/ non-equidistant data W 0 L 2 -B 27 a s p e c t s A and B 28 J.
The "Comité de s t a n d a r d i s a t i o n " of the "Société f r a n ç a i s e de biologie clinique" (Bretaudière et al. i 1979) recognizes three d i f f e r e n t sources of variability: analytic/ intra- and i n t e r - i n d i v i d u a l variability/ and p r o v i d e a non-exhaustive list of biological factors of variation/ including no less than 8 3 items. Sunderman (1975) recommends that reference values for a diagnostic test in clinical chemistry should include s p e c i f i c a t i o n s as to: 1.
Indeed/ the difficulties come to the fore once the theory has to be applied. Often» the hypotheses assumed in establishing the theory are no longer strictly valid in the laboratory. Consequently/ results are often published as "mathematically demonstrated"* while it is not at all certain that the theoretical background was pertinent. Not much attention is paid to this problem and methods are usually applied as if all theoretical conditions are verified. Emphasis will thus be placed on the need to satisfy as closely as possible all theoretical requirements in practical applications.
Annual Review of Chronopharmacology. Volume 2 by A. Reinberg